Differentiate between globular and fibrous proteins.
(i) Fibrous proteins: These proteins consist of linear thread like molecules which tend to lie side by side (parallel) to form fibres. The polypeptide chains in them are held together usually at many points by hydrogen bonds and some disulphide bonds. As a result,intermolecular forces of attraction are very’ strong and hence fibrous proteins are insoluble in water. Further, these proteins are stable to moderate changes in temperature and pH. Fibrous proteins serve as the chief structural material of animal tissues.For example, keratin in skin, hair, nails and wool, collagen in tendons, fibrosis in silk and myosin in muscles.
(ii) Globular proteins: The polypeptide chain in these proteins is folded around itself in such a way so as to give the entire protein molecule an almost spheroidal shape. The folding takes place in such a manner that hydrophobic (non-polar) parts are pushed inwards and hydrophilic (polar) parts are pushed outwards. As a result, water molecules interact strongly with the polar groups and hence globular protein are water soluble. As compared to fibrous proteins, these are very sensitive to small changes of temperature and pH. This class of proteins include all enzymes, many hormones such as insulin from pancreas, thyroglobulin from thyroid gland, etc.
The letters ' D ' or ' L' before the name of a stereoisomer of a compound indicate the correlation of configuration of that particular stereoisomer.
This refers to their relation with one of the isomers of glyceraldehydes. Predict whether the following compound has ‘D' or ‘L' configuration.
Which monosaccharide units are present in starch, cellulose and glycogen and which linkages link these units?
Assertion (A): Vitamin D can be stored in our body.
Reason (R): Vitamin D is fat soluble vitamin.
Assertion (A): β-glycosidic linkage is present in maltose.
Reason (R): Maltose is composed of two glucose units in which C-l of one glucose unit is linked to C-4 of another glucose unit.
Classify the following into monosaccharides and disaccharides. Ribose, 2-deoxyribose, maltose, galactose, fructose and lactose.
Which of the following carbohydrates are branched polymer of glucose?
(a) Amylose (b) Amylopectin (c) Cellulose (d) Glycogen
How do you explain the presence of all six carbon atoms in glucose in a straight chain?
α-Helix is a secondary structure of proteins formed by twisting of polypeptide chain into right handed screw like structures. Which type of interactions are responsible for making the a-helix structure stable?
Some enzymes are named after the reaction, where they are used. What name is given to the class of enzymes which catalyse the oxidation of one substrate with simultaneous reduction of another substrate?
Structures of glycine and alanine are given below. Show the peptide linkage in glycylalanine.
Protein found in a biological system with a unique three dimensional structure and biological activity is called a native protein. When a protein in its native form, is subjected to a physical change like change in temperature or a chemical change like, change in pH, denaturation of protein takes place. Explain the cause.
Assertion (A): Glycine must’be taken through diet.
Reason (R): It is an essential amino acid.
What products would be formed when a nucleotide from DNA containing thymine is hydrolysed?
When RNA is hydrolysed, there is no relationship among the quantities of different bases obtained. What does this fact suggest about the structure of RNA?
Proteins can be classified into two types on the basis of their molecular shape, i.e., fibrous proteins and globular proteins. Examples of globular proteins are
(a) insulin (b) keratin (c) albumin (d) myosin
In fibrous proteins, polypeptide chains are held together by
(a) van der Waals forces (b) disulphide linkage
(c) electrostatic forces of attraction (d) hydrogen bonds
Which of the following terms are correct about enzyme?
(a) Proteins (b) Dinucleotides
(c) Nucleic acids (d) Biocatalysts
Match the following enzyme given in Column I with the reactions they catalyse given in Column II.
Assertion (A): All naturally occurring a-amino acids except glycine are optically active.
Reason (R): Most naturally occurring amino acids have L-configuration.
Glucose or sucrose are soluble in water but cyclohexane and benzene (simple six membred ring compounds) are insoluble in water Explain.
Optical rotations of some compounds along with their structures are given below which of them have D configuration.
Carbohydrates are classified on the basis of their behaviour on hydrolysis and also as reducing or non-reducing sugar. Sucrose is a .
(a) monosaccharide (b) disaccharide
(c) reducing sugar (d) non-reducing sugar
Aldopentoses named ribose and 2-deoxyribose are found in nucleic acids.
What is their relative configuration?
Match the vitamins given in Column I with the deficiency disease they cause given in Column II.
