Explain the role of allosteric site in enzyme inhibition?
Some drugs do not bind to the enzyme's active site. These bind to a different site of enzyme which is called allosteric site. This bonding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot recognise it. As a result, the affinity of the substrate for the active site is reduced.
It may be noted that if the bond formed between enzyme and inhibitor is strong covalent bond and therefore cannot be broken easily, then the enzyme gets blocked permanently. The body then degrades the enzyme inhibitor complex and synthesizes new enzyme.
Compounds with antiseptic properties are
(a) CHCl, (b) CHI3
(c) Boric acid (d) 0.3 ppm aqueous solution of Cl2
Assertion (A): Chemical messengers are chemicals that enable communi ¬cation of message between two neutrons or between neurons and muscles. Reason (R): Chemicals enter the cell through receptor.
Sodium salts of some acids are Very useful as food preservatives. Suggest a few such acids.
How does the branching of hydrocarbon chain of synthetic detergents affect their biodegradability?
Which of the following compounds are administered as ant-acids?
(a) Sodium carbonate (b)Sodium Hydrogen carbonate
(c)Aluminium carbonate (d)Magnism Hydroxide
What is the advantage of using antihistamines over antacids in the treatment of acidity?
With the help of an example explain how do tranquilizers control the feeling of depression?
Write the chemical equation for preparing sodium soap from glyceryl oleate and glyceryl palmitate. Structures of these compounds are given below:
(i)(C15H31COO)3C3H5-Glyceryl palmitate
(ii)(C17H32COO)3C3H5-Glyceryl oleate
Which of the following are not used as food preservatives?
(a) Table salt (b) Sodium hydrogen carbonate
(c) Cane sugar (d) Benzoic acid
Match the class of compounds given in Column I with their functions given in Column II.
Assertion (A): Chemical messenger gives message to the cell without entering the cell.
Reason (R): Chemical messenger is received at the binding site of receptor proteins.
Which of the following are sulpha drugs?
(a) Sulphapyridine (b) Prontosil
(c) Salvarsan (d) Nardil
Aspirin is pain relieving antipyretic drug but can be used to prevent heart attack. Explain.
Between sodium hydrogen carbonate and magnesium hydroxide which is a better antacid and why?
What happens when the bond formed between an enzyme and an inhibitor is a strong covalent bond?
Assertion (A): Sulpha drug contain sulphonamide group.
Reason (R): Salvarsan is a sulpha drug.
In what respect do prontosil and Salvarsan resemble? Is there any resemblance between azo dye and prontosil? Explain.
Why are cimetidine and ranitidine better antacids than sodium hydrogencarbonate or magnesium or aluminium hydroxide?
Which of the following statements are incorrect about receptor proteins?
(a) Majority of receptor proteins are embedded in the cell membranes.
(b) The active site of receptor proteins opens on the inside region of the cell.
(c) Chemical messengers are received at the binding sites of receptor proteins.
(d) Shape of receptor does not change during attachment of messenger.
If soap has high alkali content it’irritates skin. How can the amount of excess alkali be determined? What can be the source of excess alkali?